Ataxin-1 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS7968-50, BS7968-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P54253

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB IF

All Applications: WB: 1:500~1:2000
IF: 1:50~1:200

Background: Ataxin-1, also designated spinocerebellar ataxia type 1 protein (Sca-1), is differentially expressed and localizes to both the cytoplasm and the nucleus. Mutations in Ataxin-1 are associated with the onset of the autosomal dominant neurodegenerative disorder spinocerebellar ataxia type 1 (SCA-1), which is characterized by progressive neuronal loss in the cerebellum, muscle wasting and ataxia. In Purkinje cells, where SCA-1 is predominantly observed, Ataxin-1 has been shown to directly associate with the Purkinje-enriched leucine-rich acidic nuclear protein (LANP) and the nuclear matrix-associated protein promyelocytic leukemia protein PML. In SCA-1, Ataxin-1 is mutated to encode a polyglutamine protein that forms nuclear aggregates, which interact significantly more strongly with LANP and contribute to the pathogenesis of SCA-1.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Ataxin-1 polyclonal antibody detects endogenous levels of Ataxin-1 protein.

Bioworld Molecular Weight: ~ 84 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western Blot (WB) analysis of Ataxin-1 polyclonal antibody

Alternative Name: alternative ataxin1;
Ataxin-1;
ATX1;
ATX1_HUMAN;
Atxn1;
D6S504E;
SCA1;
Spinocerebellar ataxia type 1 protein;

Immunogen: Recombinant full length Human Ataxin-1.

Conjugate: Unconjugated

Modification: Unmodified