SUN2 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS91303-50, BS91303-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q9UH99(Human) Q8BJS4(Mouse)

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, IHC FC ICC IF

All Applications: WB:1:500-1:2,000
IHC:1:50-1:200
FC:1:50-1:100
ICC/IF:1:50-1:100

Background: SUN2 (sad1/unc-84 protein-like 2), also known as UNC84B (unc-84 homolog B), FRIGG, KIAA0668 or RAB5IP, is a 717 amino acid single-pass membrane protein that contains one SUN domain and localizes to the membrane of both the nucleus and the endosome. Widely expressed in a variety of tissues, including lung, muscle and heart, SUN2 interacts with Rab 5A and may play a role in homotypic endosome fusion. The gene encoding SUN2 maps to human chromosome 22, which houses over 500 genes and is the second smallest human chromosome. Mutations in several of the genes that map to chromosome 22 are involved in the development of Phelan-McDermid syndrome, Neurofibromatosis type 2, autism and schizophrenia. Additionally, translocations between chromosomes 9 and 22 may lead to the formation of the Philadelphia Chromosome and the subsequent production of the novel fusion protein BCR-Abl, a potent cell proliferation activator found in several types of leukemias.

Purification and Purity: ProA affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Specificity: SUN2 polyclonal antibody detects endogenous levels of SUN2 protein.

Bioworld Molecular Weight: 80 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of SUN2 on rat kidney tissue lysate using anti-SUN2 antibody at 1/2,000 dilution., Immunohistochemical analysis of paraffin-embedded rat epididymis tissue using anti-SUN2 antibody. Counter stained with hematoxylin.

Alternative Name: Rab5IP, SUN2, FRIGG, KIAA0668, RAB5IP, UNC84B, FRIGG, KIAA0668, nuclear envelope protein, Protein unc-84 homolog B, Rab5 interacting protein, RAB5IP, Sad1 and UNC84 domain containing 2, Sad1 unc-84 domain protein 2, Sad1 unc84 domain protein, Sad1/unc-84 protein-like 2, Sad1/unc84 protein-like, SUN domain-containing protein 2, UNC 84B, unc84 homolog B (C. elegans), unc84 homolog B, unc84, C. elegans, homolog of, B, UNC84B,

Conjugate: Unconjugated

Modification: Unmodified