NR3C1 Polyclonal Antibody

Sizes: 60μL, 120μL, 200μL

Catalogue Numbers: E-AB-64779-60, E-AB-64779-120, E-AB-64779-200

Citations, Manuals and MSDS Available upon request.

Abbreviation: NR3C1

Target Synonym: GCCR; GCR; GCRST; GR; GRL; NR3C1

Research Areas: Cancer, Epigenetics and Nuclear Signaling, Signal Transduction

Conjugation: Unconjugated

Host: Rabbit

Species Reactivity: Human

Application: WB, IF

Isotype: IgG

Clonality: Polyclonal

UNIProt ID: P04150

Background: This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175).

Concentration: 1mg/mL

Immunogen: Recombinant fusion protein of human NR3C1 (NP_001191194.1).

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification Method: Affinity purification

Dilution: WB 1:500-1:2000 IF 1:50-1:200

Calculated MW: 49-85kDa

Observed MW: 105kDa

Storage: -20°C/One year. Avoid freeze / thaw cycles.

Shipping: Ice bag

Research Use Only