THNSL2 Polyclonal Antibody

Catalogue Numbers: BS61346-50, BS61346-100

Sizes: 50µl, 100µl

Alternative Name: Threonine synthase-like 2; TSH2; Secreted osteoclastogenic factor of activated T-cells; SOFAT

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q86YJ6

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB

All Applications: WB: 1:500~1:1000

Background: THNSL2 (threonine synthase-like 2), also known as TSH2, is a 484 amino acid protein belonging to the threonine synthase family. Utilizing pyridoxal phosphate as a cofactor, THNSL2 may function as a catabolic phospholyase on gamma and beta phosphorylated substrates. THNSL2 may also degrade O-phospho-threonine to alpha-ketobutyrate, ammonia and phosphate. Existing as four alternatively spliced isoforms, THNSL2 is encoded by a gene mapping to human chromosome 2p11.2. As the second largest human chromosome, chromosome 2 makes up approximately 8% of the human genome and contains 237 million bases encoding over 1,400 genes. A number of genetic diseases are linked to genes on chromosome 2. Harlequin icthyosis, a rare skin deformity, is associated with mutations in the ABCA12 gene. The lipid metabolic disorder sitosterolemia is associated with ABCG5 and ABCG8 gene defects. An extremely rare recessive genetic disorder, Alström syndrome, is related to mutations in the ALMS1 gene.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: THNSL2 polyclonal antibody detects endogenous levels of THNSL2 protein.

Bioworld Molecular Weight: ~ 54 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of THNSL2 polyclonal antibody at 1:500 dilution
Lane 1: HepG2 whole cell lysate(40ug)
Lane 2: H9C2 whole cell lysate(40ug)
Lane 3: RAW264.7 whole cell lysate(40ug)

Immunogen: A synthetic peptide corresponding to amino acids 103-148 in Human THNSL2.

Conjugate: Unconjugated

Modification: Unmodified