ADAM10 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS90028-50, BS90028-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: O14672(Human)

Host: Rabbit

Reactivity: Human

Applications: WB, IHC

All Applications: WB:1:500-1:2,000
IHC:1:50-1:200

Background: ADAM (a disintegrin and metalloprotease) proteins are a family of over 30 membrane-anchored, glycosylated, Zn2+ dependent proteases that are involved in cell-cell, cell-matrix interface related processes including fertilization, muscle fusion, secretion of TNFα (tumor necrosis factor α), and modulation of the neurogenic function of Notch and Delta. ADAM proteins possess a signal-domain, a pro-domain, a metalloprotease domain, a disintegrin domain (integrin ligand) a cysteine-rich region, an epidermal growth factor-like domain, a transmembrane domain and a cytoplasmic tail. ADAMs are expressed in brain, testis, epididymis, ovary, breast, placenta, liver, heart, lung, bone and muscle, and catalyze proteolysis, adhesion, fusion and intracellular signaling. ADAM10 is a TNF-processing enzyme that cleaves pro-TNF, a membrane-bound precusor protein, at Ala 76-Val 77, which causes membrane shedding of soluble TNF.

Purification and Purity: Protein affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: ADAM10 polyclonal antibody detects endogenous levels of ADAM10 protein.

Bioworld Molecular Weight: 84 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of ADAM10 on SiHa cell lysate using anti-ADAM10 antibody at 1/5,000 dilution., Immunohistochemical analysis of paraffin-embedded human prostate tissue using anti-ADAM10 antibody. Counter stained with hematoxylin.

Alternative Name: ADAM 10, ADAM10, KUZ, MADM, A disintegrin and metalloprotease domain 10, A disintegrin and metalloproteinase domain 10, AD 10, AD10, AD18, ADA10, ADAM 10, ADAM metallopeptidase domain 10, ADAM10, CD 156c, CD156c, CD156c antigen, CDw156, disintegrin and metalloproteinase domain containing protein 10, Disintegrin and metalloproteinase domain-containing protein 10, HsT 18717, HsT18717, Kuz, Kuzbanian, Kuzbanian protein homolog, Kuzbanian, Drosophila, homolog of, MADM, Mammalian disintegrin metalloprotease, Mammalian disintegrin-metalloprotease, RAK,

Immunogen: Recombinant protein

Conjugate: Unconjugated

Modification: Unmodified