Nrf2-IN-1 is an inhibitor of nuclear factor-erythroid 2-related factor 2 (Nrf2). Nrf2-IN-1 is developed for the research of acute myeloid leukemia (AML).

Product information

CAS Number: 1610022-76-8

Molecular Weight: 383.87

Formula: C21H22ClN3O2

Chemical Name: 1-[(4-tert-butylphenyl)methyl]-3-(4-chlorophenyl)-N-hydroxy-1H-pyrazole-5-carboxamide

Smiles: CC(C)(C)C1C=CC(CN2N=C(C=C2C(=O)NO)C2C=CC(Cl)=CC=2)=CC=1

InChiKey: ZFDMUUNGVLREEC-UHFFFAOYSA-N

InChi: InChI=1S/C21H22ClN3O2/c1-21(2,3)16-8-4-14(5-9-16)13-25-19(20(26)24-27)12-18(23-25)15-6-10-17(22)11-7-15/h4-12,27H,13H2,1-3H3,(H,24,26)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 260 mg/mL (677.31 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Nrf2-IN-1 (Compound 4f) (10 μM) inhibits Nrf2 activation. Nrf2-IN-1(1-20 μM; 48 hours) inhibits growth of the three AML cell. Nrf2-IN-1 (5-10 μM; 48 hours) induces apoptosis of three AML cells in vitro. Nrf2-IN-1 induces apoptotic signaling involving Bcl-2 and Bax.

In Vivo:

Nrf2-IN-1 inhibits tumor growth via apoptosis in chicken eggs.

Products are for research use only. Not for human use.