RAB7L1 Monoclonal Antibody

Catalogue Numbers: MB66716-50, MB66716-100

Sizes: 50µl, 100µl

Product: Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Swiss-Prot: O14966

Host: Mouse

Reactivity: Human

Applications: WB

All Applications: WB (1/500 - 1/1000)

Background: Rab29 (Rab7L1) is a member of the Ras GTPase superfamily of small monomeric G proteins responsible for regulation of intracellular membrane trafficking. Rab29 is involved in maintaining the integrity of the trans-Golgi network (TGN) and has been shown to play a role in the retrograde trafficking of mannose-6-phosphate receptors (M6PR) to the TGN. Rab29 is a substrate of LRRK2, a kinase associated with Parkinson’s disease (PD), and is one of five genes encoded within the PD-linked PARK16 locus. It has been shown that Rab29 recruits LRRK2 to the TGN and stimulates its kinase activity. Mimicking LRRK2 phosphorylation of Rab29 at Thr71 and Ser72 appears to suppress activation of LRRK2. Thus, Rab29 acts as a regulator of LRRK2, controlling its activation and localization.

Purification and Purity: This antibody is purified through a protein G column.

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Recognizes endogenous levels of RAB7L1 protein.

Extra Notes: Western blot analysis of RAB7L1 expression in Jurkat (A), A431 (B) whole cell lysates.

Bioworld Molecular Weight: ~ 23 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: Ras-related protein Rab-7L1; Rab-7-like protein 1

Immunogen: Recombinant fusion protein of human RAB7L1. The exact sequence is proprietary.

Conjugate: Unconjugated

Modification: Unmodified