RP101988, the major active metabolite of Ozanimod, is a selective, potent S1PR1 (sphingosine-1-phosphate receptor 1) agonist, with EC50s of 0.19 nM and 32.8 nM for S1PR1 and S1PR5, respectivlely.

Product information

Molecular Weight: 418.45

Formula: C23H22N4O4

Chemical Name: 2-[[(1S)-4-[5-(3-cyano-4-propan-2-yloxyphenyl)-1, 2, 4-oxadiazol-3-yl]-2, 3-dihydro-1H-inden-1-yl]amino]acetic acid

Smiles: CC(C)OC1=CC=C(C=C1C#N)C1=NC(=NO1)C1=CC=CC2[C@H](CCC1=2)NCC(O)=O

InChiKey: HICWSCLKDYAXPD-IBGZPJMESA-N

InChi: InChI=1S/C23H22N4O4/c1-13(2)30-20-9-6-14(10-15(20)11-24)23-26-22(27-31-23)18-5-3-4-17-16(18)7-8-19(17)25-12-21(28)29/h3-6,9-10,13,19,25H,7-8,12H2,1-2H3,(H,28,29)/t19-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

RP101988 is a substrate of P-gp and breast cancer resistance protein (BCRP) drug transporters.

Products are for research use only. Not for human use.