ADAMTS7 Polyclonal Antibody

Catalogue Numbers: BS61127-50, BS61127-100

Sizes: 50µl, 100µl

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

Swiss-Prot: Q9UKP4

Host: Rabbit

Reactivity: Human

Applications: WB

All Applications: WB: 1:1000~1:2000

Background: ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 modules) is a family of zinc-dependent proteases that are implicated in a variety of normal and pathological conditions, including arthritis and cancer. ADAMTS protein family members contain an N-terminal propeptide domain, a metalloproteinase domain, a disintegrin-like domain and a C-terminus that contains a varying number of thrombospondin type-1 (TSP-1) motifs. ADAMTS genes are primarily expressed in fetal tissues, including lung, kidney and liver. ADAMTS-7 (ADAM metallopeptidase with thrombospondin type 1 motif, 7), also known as COMPase, is a 1,686 amino acid protein that exists as two alternatively spliced isoforms. Encoded by a gene that maps to human chromosome 15q25.1, ADAMTS-7 contains eight TSP-1 motifs and binds one zinc ion per subunit. ADAMTS-7 is expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. ADAMTS-7 is also located in meniscus, bone, tendon, cartilage, synovium, fat and ligaments, and is up-regulated in articular cartilage and synovium in arthritis patients. ADAMTS-7 functions as a metalloprotease and may play a role in the degradation of COMP. ADAMTS-7 is pH dependent, with optimum pH between 7.5 and 9.5.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: ADAMTS7 polyclonal antibody detects endogenous levels of ADAMTS7 protein.

Extra Notes: Western blot (WB) analysis of ADAMTS7 polyclonal antibody at 1:1000 dilution
Lane1:A549 whole cell lysate(30ug)
Lane2:EC9706 whole cell lysate(30ug)

Bioworld Molecular Weight: ~ 230 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: A disintegrin and metalloproteinase with thrombospondin motifs 7 (EC:3.4.24.-); ADAM-TS 7; ADAM-TS7; ADAMTS-7; COMPase; ADAMTS7

Immunogen: Synthetic peptide, corresponding to Human ADAMTS7.

Conjugate: Unconjugated

Modification: Unmodified