SHC2 Polyclonal Antibody

Catalogue Numbers: BS65264-50, BS65264-100

Sizes: 50µl, 100µl

Product: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Swiss-Prot: P98077

Host: Rabbit

Reactivity: Human, Rat

Applications: WB,ELISA

All Applications: Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.

Background: domain:The PID domain mediates binding to the TrkA receptor.,function:Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.,miscellaneous:PubMed:15057824 has shown that SHC2 is poorly phosphorylated by the Trk receptors, in opposite to PubMed:12006576.,PTM:Phosphorylated on tyrosines by the Trk receptors.,similarity:Contains 1 PID domain.,similarity:Contains 1 SH2 domain.,subunit:Interacts with the Trk receptors in a phosphotyrosine-dependent manner and MEGF12. Once activated, binds to GRB2.,tissue specificity:Expressed in brain. Expressed at high level in the hypothalamus and at low level in the caudate nucleus.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Sck Polyclonal Antibody detects endogenous levels of Sck protein.

Extra Notes: Western blot analysis of lysates from Jurkat cells, using SHC2 Antibody. The lane on the right is blocked with the synthesized peptide.

Bioworld Molecular Weight: ~ 59 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: SHC2; SCK; SHCB; SHC-transforming protein 2; Protein Sck; SHC-transforming protein B; Src homology 2 domain-containing-transforming protein C2; SH2 domain protein C2

Immunogen: The antiserum was produced against synthesized peptide derived from human SHC2. AA range:261-310

Conjugate: Unconjugated

Modification: Unmodified