Fmoc-Phe-Lys(Trt)-PAB is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

Product information

CAS Number: 1116085-98-3

Molecular Weight: 863.05

Formula: C56H54N4O5

Chemical Name: (9H-fluoren-9-yl)methyl N-[(1S)-1-{[(1S)-1-carbamoyl-5-[(triphenylmethyl)amino]pentyl][4-(hydroxymethyl)phenyl]carbamoyl}-2-phenylethyl]carbamate

Smiles: NC(=O)[C@H](CCCCNC(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)N(C1C=CC(CO)=CC=1)C(=O)[C@H](CC1C=CC=CC=1)NC(=O)OCC1C2=CC=CC=C2C2=CC=CC=C21

InChiKey: YYQHCELGLDFYGB-XWQGWOARSA-N

InChi: InChI=1S/C56H54N4O5/c57-53(62)52(31-17-18-36-58-56(42-21-7-2-8-22-42,43-23-9-3-10-24-43)44-25-11-4-12-26-44)60(45-34-32-41(38-61)33-35-45)54(63)51(37-40-19-5-1-6-20-40)59-55(64)65-39-50-48-29-15-13-27-46(48)47-28-14-16-30-49(47)50/h1-16,19-30,32-35,50-52,58,61H,17-18,31,36-39H2,(H2,57,62)(H,59,64)/t51-,52-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

Products are for research use only. Not for human use.