THP-PEG4-Pyrrolidine(N-Boc)-CH2OH is a PEG-based PROTAC linker can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523).

Product information

CAS Number: 2378261-80-2

Molecular Weight: 477.59

Formula: C23H43NO9

Chemical Name: tert-butyl (2S,4R)-2-(hydroxymethyl)-4-[2-(2-{2-[2-(oxan-2-yloxy)ethoxy]ethoxy}ethoxy)ethoxy]pyrrolidine-1-carboxylate

Smiles: CC(C)(C)OC(=O)N1C[C@@H](C[C@H]1CO)OCCOCCOCCOCCOC1CCCCO1

InChiKey: ZKEBNPQGNDNRDY-MCOCGALXSA-N

InChi: InChI=1S/C23H43NO9/c1-23(2,3)33-22(26)24-17-20(16-19(24)18-25)30-14-12-28-10-8-27-9-11-29-13-15-32-21-6-4-5-7-31-21/h19-21,25H,4-18H2,1-3H3/t19-,20+,21?/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

PROTAC K-Ras Degrader-1 is potent K-Ras degrader based PROTAC, exhibits ≥70% degradation efficacy in SW1573 cells. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Products are for research use only. Not for human use.