Recombinant Human NTPDase 2/ENTPD2 Protein (aa 29-460, His Tag)(Active) Size: 50μg Catalogue Numbers: PKSH031019-50 Citations, Manuals and MSDS Available upon request. Abbreviation: NTPDase 2; ENTPD2 Target Synonym: CD39L1; NTPDase-2; RP11-229P13.11-001 UNIProt ID: Q9Y5L3 Research Areas: Neuroscience; Cancer; metabolism Target Species: Human Expression Host: Baculovirus-Insect Cells Fusion Tag: N-His Accession: Q9Y5L3 Background: NTPDase 2, also known as ENTPD2, belongs to the ecto-nucleoside triphosphate diphosphohydrolase family (E-NTPDase). Members of E-NTPDase family are nucleotidases able to hydrolyze 5′ -nucleoside tri- and/or diphosphates; the main role of these enzymes is the termination of purinergic signaling. NTPDases are ubiquitous and were previously shown in other parasites including the trypanosomatides of genus Leishmania and in T. brucei. NTPase activity would act as a timer and is crucial to T. gondii infection. In L. pneumophila it was demonstrated that an E-NTPDase, similar to CD39, is essential for intracellular bacterial multiplication. NTPDase 2 is an integral membrane protein. In the nervous system, it could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Alternative splicing of NTPDase 2 gene results in multiple transcript variants. Sequence: Thr 29-Asp460 Purity: > 85 % as determined by reducing SDS-PAGE. Formulation: Lyophilized from sterile 20mM Tris, 500mM NaCl, pH 7.4 Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. Reconstitution: Please refer to the printed manual for detailed information. Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method. Calculated MW: 49.3 kDa Observed MW: 59 kDa Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. Shipping: This product is provided as lyophilized powder which is shipped with ice packs. Research Use Only