CD46 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS90250-50, BS90250-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P15529(Human) Q9Z0M4(Rat)

Host: Rabbit

Reactivity: Human, Rat

Applications: WB, ICC IHC

All Applications: WB:1:1,000-1:5,000
ICC:1:50-1:200
IHC:1:50-1:200

Background: CD46, also called membrane cofactor protein (MCP), is a transmembrane glycoprotein that exists as a non-disulfide-linked dimer. CD46 regulates the complement cascade by inhibiting C3b and C4b deposited on self tissue. CD46 is a cofactor that binds to C3b and C4b, allowing their degradation by a plasma serine protease called factor I. This function resides in the complement control protein repeats (CCPs), with CCP1-4 essential for regulation. CD46 is widely distributed on thymocytes, T cells, B cells, monocytes, granulocytes, NK cells, platelets, endothelial cells, epithelial cells, fibroblasts, placenta and sperm, but not on erythrocytes. It is the major high affinity receptor for measles virus and human herpes virus. Mouse cells ubiquitously express CRRY, which is a functional ortholog of human decay-accelerating factor (DAF; CD55) and membrane cofactor protein (MCP; CD46).

Purification and Purity: ProA affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: CD46 polyclonal antibody detects endogenous levels of CD46 protein.

Bioworld Molecular Weight: 55 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of CD46 on Siha and PC-3M cell lysates using anti-CD46 antibody at 1/1,000 dilution., ICC staining CD46 in PC-3M cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Alternative Name: CD46, MCP, MIC10, AHUS2, Antigen defined by monoclonal antibody TRA 2 10, Antigen identified by monoclonal antibody TRA 2 10, CD46, CD46 antigen, CD46 antigen complement regulatory protein, CD46 molecule, CD46 molecule complement regulatory protein, Complement membrane cofactor protein, MCP, MCP, Measles virus receptor, membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen), Membrane cofactor protein, MGC26544, MIC10, TLX, TRA2.10, Trophoblast leucocyte common antigen, Trophoblast leukocyte common antigen, Trophoblast lymphocyte cross reactive antigen,

Immunogen: Recombinant protein

Conjugate: Unconjugated

Modification: Unmodified