DNA Ligase III rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES2182-50, ES2182-100

Citations, Manuals and MSDS Available upon request.

Background: This gene is a member of the DNA ligase family. Each member of this family encodes a protein that catalyzes the joining of DNA ends but they each have a distinct role in DNA metabolism. The protein encoded by this gene is involved in excision repair and is located in both the mitochondria and nucleus, with translation initiation from the upstream start codon allowing for transport to the mitochondria and translation initiation from a downstream start codon allowing for transport to the nucleus. Additionally, alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008],

Alternate Name: LIG3; DNA ligase 3; DNA ligase III; Polydeoxyribonucleotide synthase [ATP] 3

Source: Rabbit

Applications: WB; ELISA

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.

Reactivity: Human; Mouse; Rat

Immunogen: Synthesized peptide derived from DNA Ligase III . at AA range: 110-190

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 100kD

Human Gene ID: 3980

Human SWISS Prot NO: P49916

Subcellular Location: [Isoform 1]: Mitochondrion. Contains an N-terminal mitochondrial transit peptide.; [Isoform 2]: Mitochondrion. Contains an N-terminal mitochondrial transit peptide.; [Isoform 3]: Nucleus. Lacks the N-terminal mitochondrial transit peptide.; [Isoform 4]: Nucleus. Lacks the N-terminal mitochondrial transit peptide.

Research Use Only