Panamesine (EMD 57445) is a sigma receptor ligand, which has a high affinity (IC50 6 nM) and selectivity for sigma binding sites. Panamesine is a potential atypical neuroleptic agent.

Product information

CAS Number: 139225-22-2

Molecular Weight: 426.46

Formula: C23H26N2O6

Chemical Name: (5S)-5-{[4-(2H-1,3-benzodioxol-5-yl)-4-hydroxypiperidin-1-yl]methyl}-3-(4-methoxyphenyl)-1,3-oxazolidin-2-one

Smiles: COC1C=CC(=CC=1)N1C[C@H](CN2CCC(O)(CC2)C2=CC3OCOC=3C=C2)OC1=O

InChiKey: NINYZUDVKTUKIA-IBGZPJMESA-N

InChi: InChI=1S/C23H26N2O6/c1-28-18-5-3-17(4-6-18)25-14-19(31-22(25)26)13-24-10-8-23(27,9-11-24)16-2-7-20-21(12-16)30-15-29-20/h2-7,12,19,27H,8-11,13-15H2,1H3/t19-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 125 mg/mL (293.11 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

Panamesine (EMD 57445; 0.3, 1, 3, 30 mg/kg) induces a dose-dependent increase of c-fos expression in several cortical areas with the strongest signals in the piriform cortex.

Products are for research use only. Not for human use.