Synuclein-α (E123) Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS1596-50, BS1596-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P37840

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: IHC

All Applications: IHC: 1:50~1:200

Background: The synuclein family members, including α-synuclein (also designated NACP for non-β amyloid component) and β-synuclein, are predominantly expressed in the brain and are speculated to be involved in synaptic regulation and neuronal plasticity. α-synuclein is localized to neuronal cell bodies and synapses. α-synuclein was first identified as a component of Alzheimer’s disease amyloid plaques. Abnormal platelet function in Alzheimer’s disease has been demonstrated. During megakaryocytic differentiation α-synuclein was found to be up-regulated, while β-synuclein is down-regulated, indicating that coordinate expression of synucleins may be important during hematopoetic cell differentiation. A mutant form of α-synuclein has been found in patients with early onset Parkinson’s disease.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Immunohistochemistry (IHC) analyzes of SNCA (E123) pAb in paraffin-embedded human breast carcinoma tissue.

Bioworld Molecular Weight: ~ 18 kDa

Specificity: Synuclein-α (E123) polyclonal antibody detects endogenous levels of Synuclein-α protein.

Alternative Name: Alpha-synuclein; α-synuclein; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP; SNCA; NACP; PARK1

Immunogen: Synthetic peptide, corresponding to amino acids 100-150 of Human Synuclein-α.

Conjugate: Unconjugated

Modification: Unmodified