Claudin-9 Polyclonal Antibody

Catalogue Numbers: BS61303-50, BS61303-100

Sizes: 50µl, 100µl

Alternative Name: Claudin-9; CLDN9;

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: O95484

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB

All Applications: WB: 1:500~1:1000

Background: The claudin superfamily consists of many structurally related proteins in humans (1). These proteins are important structural and functional components of tight junctions in paracellular transport (1,2). Claudins are located in both epithelial and endothelial cells in all tight junction-bearing tissues (1). Three classes of proteins are known to localize to tight junctions, including the claudins, Occludin and junction adhesion molecule (3). Claudins, which consist of four transmembrane domains and two extracellular loops make up tight junction strands (4). Claudin expression is often highly restricted to specfic regions of different tissues and may have an important role in transcellular transport through tight junctions (5). Claudin-9 is highly similar to claudin-3 (also designated clostridium perfringens enterotoxin receptor) (6). Claudin-9 is expressed in simian virus (SV)40-immortalized human corneal epithelial (THCE) cells (7). The human claudin-9 gene maps to chromosome 16p13.3 (6).

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -26°C long term. Avoid freeze-thaw cycles.

Specificity: Claudin-9 polyclonal antibody detects endogenous levels of Claudin-9 protein.

Bioworld Molecular Weight: ~ 23 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of Claudin-9 polyclonal antibody at 1:500 dilution
Line1:Hela whole cell lysate
Line2:H9C2 whole cell lysate
Line3:Raw264.7 whole cell lysate

Immunogen: A synthetic peptide corresponding to residues in Human Claudin-9.

Conjugate: Unconjugated

Modification: Unmodified