Vimirogant (VTP-43742) is a potent, selective, and orally active RORγt inhibitor (Ki=3.5 nM; IC50=17 nM). Vimirogant exhibits >1000-fold selectivity versus the RORα and RORβ isotypes. Vimirogant inhibits Th17 differentiation and IL-17A secretion from mouse splenocytes (IC50=57 nM) without affecting Th1, Th2, or Treg cell differentiation. Vimirogant has the potential for autoimmune disorders research.

Product information

CAS Number: 1802706-04-2

Molecular Weight: 552.65

Formula: C27H35F3N4O3S

Chemical Name: (7S)-N-{[5-(ethanesulfonyl)pyridin-2-yl]methyl}-7-(propan-2-yl)-6-{[(1r,4r)-4-(trifluoromethyl)cyclohexyl]methyl}-5H,6H,7H-pyrrolo[3,4-b]pyridine-3-carboxamide

Smiles: CC(C)[C@H]1C2=NC=C(C=C2CN1C[C@@H]1CC[C@H](CC1)C(F)(F)F)C(=O)NCC1=CC=C(C=N1)S(=O)(=O)CC

InChiKey: XUYMIRYNRKXKOR-HMHJJOSWSA-N

InChi: InChI=1S/C27H35F3N4O3S/c1-4-38(36,37)23-10-9-22(31-14-23)13-33-26(35)19-11-20-16-34(25(17(2)3)24(20)32-12-19)15-18-5-7-21(8-6-18)27(28,29)30/h9-12,14,17-18,21,25H,4-8,13,15-16H2,1-3H3,(H,33,35)/t18-,21-,25-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Vimirogant inhibits the secretion of IL-17A from activated hPBMCs (IC50=18 nM) and human whole blood (IC50=192 nM).

In Vivo:

In the MOG35-55/CFA immunized mouse EAE model, Vimirogant (p.o.) significantly suppresses clinical symptoms, demyelination and mRNA expression of multiple inflammatory markers in the spinal cord.

Products are for research use only. Not for human use.