MCOLN3 Polyclonal Antibody

Catalogue Numbers: BS67578-50, BS67578-100

Sizes: 50µl, 100µl

Product: Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Swiss-Prot: Q8TDD5

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB

All Applications: WB (1/500 - 1/1000)

Background: Nonselective ligand-gated cation channel probably playing a role in the regulation of membrane trafficking events. Acts as Ca2+-permeable cation channel with inwardly rectifying activity .
Mediates release of Ca2+ from endosomes to the cytoplasm, contributes to endosomal acidification and is involved in the regulation of membrane trafficking and fusion in the endosomal pathway .
Does not seem to act as mechanosensory transduction channel in inner ear sensory hair cells. Proposed to play a critical role at the cochlear stereocilia ankle-link region during hair-bundle growth (By similarity). Involved in the regulation of autophagy. Through association with GABARAPL2 may be involved in autophagosome formation possibly providing Ca2+ for the fusion process (By similarity).
Through a possible and probably tissue-specific heteromerization with MCOLN1 may be at least in part involved in many lysosome-dependent cellular events .
Possible heteromeric ion channel assemblies with TRPV5 show pharmacological similarity with TRPML3 .

Purification and Purity: The antibody was purified by immunogen affinity chromatography.

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Recognizes endogenous levels of MCOLN3 protein.

Extra Notes: Western blot analysis of MCOLN3 expression in SGC7901 (A), HCT116 (B), Panc1 (C), mouse lung (D), mouse kidney (E), rat lung (F), rat kidney (G) whole cell lysates.

Bioworld Molecular Weight: ~ 60 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: Mucolipin-3

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human MCOLN3. The exact sequence is proprietary.

Conjugate: Unconjugated

Modification: Unmodified