Recombinant Mouse BAFFR/TNFRSF13C/CD268 Protein (Fc Tag)(Active)

Size: 100μg

Catalogue Number: PKSM040719-100

Citations, Manuals and MSDS Available upon request.

Abbreviation: BAFFR; TNFRSF13C; CD268

Target Symptom: 2010006P15Rik; BAFF-R; Baffr; Bcmd; Bcmd-1; Bcmd1; Lvis22

Target Species: Mouse

Expression Host: HEK293 Cells

Application: ELISA

Fusion Tag: C-hFc

UNIProt ID: Q9D8D0

Accession: Q9D8D0-1

Background: Tumor necrosis factor receptor superfamily, member 13C (TNFRSF13C) also known as B-cell-activating factor receptor (BAFFR) and CD268 antigen, is a member of the tumor necrosis factor receptor superfamily. A tumor necrosis factor receptor (TNFR), or death receptor, is a trimeric cytokine receptor that binds tumor necrosis factors (TNF). The receptor cooperates with an adaptor protein which is important in determining the outcome of the response. Members of the TNF receptor superfamily (TNFRSF) have crucial roles in both innate and adaptive immunity and in cellular apoptosis process. Apoptosis is a cell suicide mechanism that enables metazoans to control cell number in tissues and to eliminate individual cells that threaten the animal's survival. Certain cells have unique sensors, termed death receptors or tumour necrosis factor (TNFR), on their surface. Tumour necrosis factors (TNFR) detect the presence of extracellular death signals and, in response, they rapidly ignite the cell's intrinsic apoptosis machinery. It has been proposed that abnormally high levels of BAFFR/TNFRSF13C (CD268) may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells.

Activity: Immobilized human BAFF at 10 μg/ml (100 μl/well) can bind mouse BAFFR-Fc, The EC50 of mouse BAFFR-Fc is 0.14-0.32 μg/ml.

Sequence: Met 1-Ala 71

Purity: > 90 % as determined by reducing SDS-PAGE.

Formulation: Lyophilized from sterile PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Reconstitution: Please refer to the printed manual for detailed information.

Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.

Calculated MW: 33.7 kDa

Observed MW: 40-45 kDa

Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Research Use Only