AR-β2 (R228) Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS2392-50, BS2392-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P07550

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: IHC

All Applications: IHC: 1:50~1:200

Background: Beta 2 Adrenergic Receptor is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene contains no introns in either its coding or untranslated sequences. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes. Expression of the beta 2 Adrenergic Receptor has been reported in adipose, blood, brain, heart, lung, nose, pancreas, skeletal muscle, skin, and vessel.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Immunohistochemistry (IHC) analyzes of AR-β2 (R228) pAb in paraffin-embedded human tonsil carcinoma tissue at 1:50.

Bioworld Molecular Weight: ~ 47 kDa, 68 kDa (glycosylated), 95 kDa (Dimer)

Specificity: AR-β2 (R228) polyclonal antibody detects endogenous levels of AR-β2 protein.

Alternative Name: ADRB2; ADRB2R; ADRBR; B2AR; BAR; BETA2AR; Beta-2 adrenergic receptor; ARβ2

Immunogen: Synthetic peptide, corresponding to amino acids 201-250 of Human AR-β2.

Conjugate: Unconjugated

Modification: Unmodified