Phospho-KCNQ2/3/4/5 (Thr217/Thr246/Thr223/Thr251) Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BZ16487-50, BZ16487-100

Product: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Swiss-Prot: O43526/O43525/P56696/Q9NR82

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: IHC-P, ELISA

All Applications: IHC: 1/50-1/100 ELISA: 1/10000

Background: The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in KCNQ2 are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1). At least five transcript variants encoding five different isoforms have been found for this gene.

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: IgG

Bioworld Molecular Weight: -

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: EnzymeLinked Immunosorbent Assay for Immunogen Phospho-peptide and NonPhospho-peptide , using Kv7. 3/KCNQ3 (Phospho-Thr24antibody, Immunohistochemical analysis of paraffin-embedded Human tonsils using Phospho-KCNQ2/3/4/5 antibody. Sample with blocking peptide on the right. High-pressure and temperature Sodium Citrate pH 6. 0 was used for antigen retrieval.

Alternative Name: KCNQ2; Potassium voltage-gated channel subfamily KQT member 2; KQT-like 2; Neuroblastoma-specific potassium channel subunit alpha KvLQT2; Voltage-gated potassium channel subunit Kv7.2; KCNQ3; Potassium voltage-gated channel subfamily KQT me

Immunogen: The antiserum was produced against synthesized peptide derived from human Kv7.3/KCNQ3 around the phosphorylation site of Thr246. AA range:191-240

Conjugate: Unconjugated

Modification: Phosphorylated