SJ000025081 is a dihydropyridine and acts as a potent antimalarial agent. SJ000025081 results in an obvious suppression of the parasitemia in a murine malaria model infected with P. yoelii.

Product information

CAS Number: 421571-66-6

Molecular Weight: 479.54

Formula: C28H30FNO5

Chemical Name: propyl 7-(3,4-dimethoxyphenyl)-4-(2-fluorophenyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate

Smiles: CC1NC2CC(CC(=O)C=2C(C=1C(=O)OCCC)C1=CC=CC=C1F)C1=CC(OC)=C(C=C1)OC

InChiKey: JYAOIVVCGRSAFZ-UHFFFAOYSA-N

InChi: InChI=1S/C28H30FNO5/c1-5-12-35-28(32)25-16(2)30-21-13-18(17-10-11-23(33-3)24(15-17)34-4)14-22(31)27(21)26(25)19-8-6-7-9-20(19)29/h6-11,15,18,26,30H,5,12-14H2,1-4H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

SJ000025081 (intraperitoneal injection; 25 mg/kg; single dose; suspension in 1% methylcellulose) exhibits a good PK profile, the Cmax, Cmax/Dose, Tmax and AUC values are 0.224 µg/ml, 0.0113 µg/ml per mg/ml, 1.0 h and 0.224 µg.h/ml, respectively. SJ000025081 (intraperitoneal injection; 5-100 mg/kg; twice-daily; 3 days) exhibits an antimalarial activity in a dose-dependent manner and displays efficacy in a murine malaria model infected with P. yoelii. SJ000025081 can result in a 90% suppression of the parasitemia.

Products are for research use only. Not for human use.