IGF-I Receptor β (phospho-Tyr980) rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES15513-50, ES15513-100

Citations, Manuals and MSDS Available upon request.

Background: This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014],

Alternate Name: Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]

Source: Rabbit

Applications: WB

Dilution: WB 1:1000-2000

Reactivity: Human; Mouse; Rat

Immunogen: Synthesized phosho peptide around human IGF-I Receptor β (Tyr980)

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): pro: 155kD, recetor beta: 95kD

Human Gene ID: 3480

Human SWISS Prot NO: P08069

Subcellular Location: Cell membrane; Single-pass type I membrane protein.

Research Use Only