KDM2A Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB10911-50, MB10911-100

Product: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Swiss-Prot: Q9Y2K7

Host: Rabbit

Reactivity: Human

Applications: WB,IHC-F,IHC-P,ICC/IF,IP

All Applications: WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200 IP: 1/20

Background: Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis.

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of FBXL11 in JurkatLysates using KDM2A antibody.

Bioworld Molecular Weight: Calculated MW: 133 kDa; Observed MW: 133 kDa

Specificity: IgG

Alternative Name: FBL7; CXXC8; FBL11; FBXL11; JHDM1A; LILINA

Immunogen: A synthetic peptide of human FBXL11

Conjugate: Unconjugated

Modification: Unmodified