CXCR3 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS90349-50, BS90349-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P49682(Human)

Host: Rabbit

Reactivity: Human

Applications: WB, ICC/IF, IP,

All Applications: WB:1:500-1:2,000
ICC:1:50-1:200

Background: The C-X-C or α chemokine family is characterized by a pair of cysteine residues separated by a single amino acid and primarily functions as chemoattractants for neutrophils. The C-X-C family includes IL-8, NAP-2, MSGA and stromal cell derived factor-1 (SDF-1). SDF-1 was originally described as a pre-B cell stimulatory factor, but has since been shown to function as a potent chemoattractant for T cells and monocytes but not neutrophils. Receptors for the C-X-C family are G protein-coupled, seven pass transmembrane domain proteins which include IL-8RA, IL-8RB, CXCR-3 and fusin (also designated LESTR or CXCR-4). CXCR-3, also known as IP-10/MIG receptor, mediates Ca2+ mobilization and chemotaxis in response to the C-X-C chemokines IP-10 and MIG. CXCR-3 is highly expressed in IL-2-activated T lymphocytes, but not in resting T lymphocytes, B lymphocytes, monocytes or granulocytes.

Purification and Purity: ProA affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: CXCR3 polyclonal antibody detects endogenous levels of CXCR3 protein.

Bioworld Molecular Weight: 41 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of CXCR3 on Hela cell using anti-CXCR3 antibody at 1/1,000 dilution., ICC staining CXCR3 in A431 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Alternative Name: CXC-R3, CXCR-3, IP-10 receptor, IP-10 receptor, CD183, CXCR3, GPR9, C-X-C chemokine receptor type 3, CD 183, CD182, CD183, Chemokine (C X C motif) receptor 3, Chemokine (C X C) receptor 3, Chemokine CXC Motif Receptor 3, CKR L2, CKR-L2, CKRL2, CMKAR3, CXC-R3, CXCR-3, CXCR3, CXCR3, G Protein Coupled Receptor 9, G protein-coupled receptor 9, GPR9, Interferon-inducible protein 10 receptor, IP-10 receptor, IP10, IP10 R, IP10 receptor, IP10-R, IP10R, Mig R, Mig receptor, Mig-R, MIGR,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodified