ND-336 is a selective inhibitor of matrix metalloproteinase (MMP)-2, MMP-9, and MMP-14, with Kis of 85, 150, and 120 nM, respectively. ND-336 accelerates diabetic wound healing in mice by lowering inflammation and by enhancing angiogenesis and re-epithelialization of the wound.

Product information

CAS Number: 1807453-83-3

Molecular Weight: 371.90

Formula: C16H18ClNO3S2

Chemical Name: 1-(4-{4-[(thiiran-2-yl)methanesulfonyl]phenoxy}phenyl)methanamine hydrochloride

Smiles: Cl.NCC1C=CC(=CC=1)OC1C=CC(=CC=1)S(=O)(=O)CC1CS1

InChiKey: DRGIZFGSEKSFIC-UHFFFAOYSA-N

InChi: InChI=1S/C16H17NO3S2.ClH/c17-9-12-1-3-13(4-2-12)20-14-5-7-16(8-6-14)22(18,19)11-15-10-21-15;/h1-8,15H,9-11,17H2;1H

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

ND-336 accelerates diabetic wound healing by decreasing inflammation and by enhancing angiogenesis and re-epithelialization of the wound, thus reversing the pathological condition. ND-336 (0.05-0.01 mg; topical application; daily for 14 day) accelerates diabetic wound healing.

Products are for research use only. Not for human use.