Haptoglobin Polyclonal Antibody Sizes: 50μL, 100μL Catalogue Numbers: RA25630-50, RA25630-100 Citations, Manuals and MSDS Available upon request. Background: haptoglobin (HP) Homo sapiens This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. The protein encoded also exhibits antimicrobial activity against bacteria. A similar duplicated gene is located nex Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions: -20°C/1 year Recommended dilutions: IHC-p 1:50-200, ELISA 1:10000-20000 Alternative Names: Haptoglobin (Zonulin) [Cleaved into: Haptoglobin alpha chain; Haptoglobin beta chain] Applications: IHC-p; IF (paraffin section) ; ELISA Species Cross-Reactivity: Human; Rat; Mouse GeneID (Human): 3240 SWISS: P00738 Source: Rabbit Research Use Only