Clenbuterol is a sympathomimetic β2-adrenoceptor agonist. β2-adrenoceptor agonists, mainly long-acting β2-adrenoceptor agonists, are an important pharmacological approach to induce bronchodilation in patients with chronic obstructive pulmonary disease. In vitro: A hormone dependent human breast cancer cell line was treated with different concentrations of clenbuterol. It was found that clenbuterol could stimulate cell proliferation at low concentrations, but the effect was less marked and significant compared with oestradiol. Probably clenbuterol elicited cell proliferation via a different mechanism, because it did not affect the cellular oestrogen receptor concentration . In vivo: Clenbuterol was administered to Fischer-344 rats, at a dose of 1.5 mg/kg/24 h for 3 weeks. The weights of five hindlimb muscles and carcass protein and fat content were determined. Results showed that clenbuterol treatment could increase the weight of skeletal muscles of all animals. Similarly, clenbuterol increased carcass protein conten, leading to the reduced carcass fat content . Clinical trial: Clenbuterol was compared with terbutaline during a 5-week single-blind crossover study in patients with chronic airways obstruction. Both clenbuterol and terbutaline could significantly improve baseline FEV1 and the bronchodilator effects were similar, suggesting that clenbuterol was a good alternative drug for treatment of chronic airways obstruction .

Product information

CAS Number: 21898-19-1

Molecular Weight: 313.65

Formula: C12H19Cl3N2O

Chemical Name: 1-(4-amino-3,5-dichlorophenyl)-2-(tert-butylamino)ethan-1-ol hydrochloride

Smiles: Cl.CC(C)(C)NCC(O)C1=CC(Cl)=C(N)C(Cl)=C1

InChiKey: OPXKTCUYRHXSBK-UHFFFAOYSA-N

InChi: InChI=1S/C12H18Cl2N2O.ClH/c1-12(2,3)16-6-10(17)7-4-8(13)11(15)9(14)5-7;/h4-5,10,16-17H,6,15H2,1-3H3;1H

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.