Cyclin D2 (6E11) Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB3016-50, MB3016-100

Product: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Swiss-Prot: P30279

Host: Mouse

Reactivity: Human

Applications: WB

All Applications: WB: 1/500-1/1000

Background: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK4 or CDK6 and functions as a regulatory subunit of the complex, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and Ticular tumors. Mutations in this gene are associated with megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 (MPPH3).

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of Cyclin D2 in CHO-K1Lysates and CHO-K1 transfected by Cyclin D2fragment EGFP fusion proteinlysates using Cyclin D2 antibody.

Bioworld Molecular Weight: Calculated MW: 33 kDa; Observed MW: 38 kDa

Specificity: IgG2b

Alternative Name: KIAK0002.

Immunogen: Purified recombinant human Cyclin D2 protein fragments expressed in E.coli.

Conjugate: Unconjugated

Modification: Unmodified