IMP-3 Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB9303-50, MB9303-100

Product: Mouse IgG1, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: O00425(Human) Q9CPN8(Mouse)

Host: Mouse

Reactivity: Human, Mouse, Rat

Applications: WB, IHC ICC FC

All Applications: WB:1:1,000-1:2,000
ICC:1:50
IHC:1:50-1:200
FC:1:50-1:100

Background: Insulin like growth factor 2 mRNA binding proteins (IGF2BPs) bind RNA and influence RNA synthesis and metabolism. IGF2BP1, also known as coding region determinant-binding protein/insulin-like growth factor II mRNA-binding protein (CRD-BP), IMP1 or VICKZ1; IGF2BP2 (IMP2, VICKZ2, p62); and IGF2BP2 (IMP3, KOC1, VICKZ3) contain a unique combination of RNA recognition motifs and four hnRNP K homology domains. IGF2BP1 is abundant in embryonal tissues and is expressed in 81% of colon cancers, 73% of sarcomas and 58.5% of breast cancers. It recognizes c-Myc, IGF-II and t mRNAs, and H19 RNA, and plays a major role in proliferation of K-562 cells by an IGF-II-dependent mechanism. IGF2BP2 binds the 5' UTR of IGF-II mRNA and influences tumor cell growth, in which IGF2BP2 is associated with apoptosis induced by tretinoin. IGF2BP3 knockdown by RNA interference decreases levels of IGF-II protein without affecting IGF-II, c-Myc, or β Actin mRNA and H19 RNA levels. IGF2BP3 is a marker for carcinomas and high-grade dysplastic lesions of pancreatic ductal epithelium.

Purification and Purity: ProA affinity purified

Storage and Stability: Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.

Specificity: IMP-3 monoclonal antibody detects endogenous levels of IMP-3 protein.

Bioworld Molecular Weight: 62 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of IMP3 on Hela lysate using anti-IMP3 antibody at 1/1,000 dilution., Western blot analysis of IMP3 on 293T lysate using anti-IMP3 antibody at 1/1,000 dilution.

Alternative Name: IGF2 mRNA-binding protein 3, IMP-3, hKOC, IGF2BP3, IMP3, KOC1, VICKZ3, Cancer/testis antigen 98, CT98, DKFZp686F1078, hKOC, IF2B3, IGF II mRNA binding protein 3, IGF-II mRNA-binding protein 3, IGF2 mRNA binding protein 3, IGF2 mRNA-binding protein 3, IGF2BP3, IMP 3, IMP-3, Insulin like growth factor 2 mRNA binding protein 3, Insulin-like growth factor 2 mRNA-binding protein 3, KH domain containing protein overexpressed in cancer, KH domain-containing protein overexpressed in cancer, KOC 1, KOC1, VICKZ 3, VICKZ family member 3, VICKZ3,

Immunogen: Recombinant protein

Conjugate: Unconjugated

Modification: Unmodified