JTP10-△-TATi TFA is a selective JNK2 peptide inhibitor, with an IC50 of 92 nM, exhibiting 10-fold selectivity for JNK2 over JNK1 and JNK3.

Product information

Molecular Weight: 2833.28

Formula: C120H213F3N48O28

Chemical Name: Ac-PKRPTTLNLF-{Ahx}-RRRQRRKKRG-NH2

Smiles: CC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCCCCCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O.OC(=O)C(F)(F)F

InChiKey: LOGXBOXNKWVOMN-AQXJIVQXSA-N

InChi: InChI=1S/C118H212N48O26.C2HF3O2/c1-64(2)59-81(159-106(187)84(62-88(123)171)161-104(185)82(60-65(3)4)162-109(190)91(66(5)167)164-110(191)92(67(6)168)163-108(189)86-42-28-58-166(86)111(192)80(40-26-56-146-118(137)138)158-101(182)75(33-15-18-48-121)157-107(188)85-41-27-57-165(85)68(7)169)103(184)160-83(61-69-29-10-8-11-30-69)105(186)155-78(39-25-55-145-117(135)136)98(179)149-70(34-20-50-140-112(125)126)93(174)139-49-19-9-12-43-90(173)148-72(36-22-52-142-114(129)130)95(176)156-79(44-45-87(122)170)102(183)154-77(38-24-54-144-116(133)134)100(181)153-76(37-23-53-143-115(131)132)99(180)152-74(32-14-17-47-120)97(178)151-73(31-13-16-46-119)96(177)150-71(35-21-51-141-113(127)128)94(175)147-63-89(124)172;3-2(4,5)1(6)7/h8,10-11,29-30,64-67,70-86,91-92,167-168H,9,12-28,31-63,119-121H2,1-7H3,(H2,122,170)(H2,123,171)(H2,124,172)(H,139,174)(H,147,175)(H,148,173)(H,149,179)(H,150,177)(H,151,178)(H,152,180)(H,153,181)(H,154,183)(H,155,186)(H,156,176)(H,157,188)(H,158,182)(H,159,187)(H,160,184)(H,161,185)(H,162,190)(H,163,189)(H,164,191)(H4,125,126,140)(H4,127,128,141)(H4,129,130,142)(H4,131,132,143)(H4,133,134,144)(H4,135,136,145)(H4,137,138,146);(H,6,7)/t66-,67-,70+,71+,72+,73+,74+,75+,76+,77+,78+,79+,80+,81+,82+,83+,84+,85+,86+,91+,92+;/m1./s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

JTP10-△-TATi TFA inhibits the migration of PyVMTjnk2+/+ cells and PyVMTjnk2-/- cells expressing GFP-JNK2α.

Products are for research use only. Not for human use.