MS67, CAS No. 2407452-77-9, is a potent and selective WD40 repeat domain protein 5 (WDR5) degrader with a Kd of 63 nM. MS67 is inactive against other protein methyltransferases, kinases, GPCRs, ion channels, and transporters. MS67 shows potent acticancer effects.

Product information

CAS Number: 2407452-77-9

Molecular Weight: 1030.14

Formula: C52H59F4N9O7S

Chemical Name: N-{2'-fluoro-5'-[({[(2S)-1-[(2S, 4R)-4-hydroxy-2-{[(1S)-1-[4-(4-methyl-1, 3-thiazol-5-yl)phenyl]ethyl]carbamoyl}pyrrolidin-1-yl]-3, 3-dimethyl-1-oxobutan-2-yl]carbamoyl}methyl)carbamoyl]-4-[(3R, 5S)-3, 4, 5-trimethylpiperazin-1-yl]-[1, 1'-biphenyl]-3-yl}-6-oxo-4-(trifluoromethyl)-1, 6-dihydropyridine-3-carboxamide

Smiles: CC(C)(C)[C@H](NC(=O)CNC(=O)C1=CC=C(F)C(=C1)C1=CC(NC(=O)C2=CNC(=O)C=C2C(F)(F)F)=C(C=C1)N1C[C@H](C)N(C)[C@H](C)C1)C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@@H](C)C1C=CC(=CC=1)C1SC=NC=1C

InChiKey: HBHSDSLZXDASLT-FLKKWHKHSA-N

InChi: InChI=1S/C52H59F4N9O7S/c1-27-23-64(24-28(2)63(27)8)41-16-14-33(18-40(41)61-48(70)37-21-57-43(67)20-38(37)52(54,55)56)36-17-34(13-15-39(36)53)47(69)58-22-44(68)62-46(51(5,6)7)50(72)65-25-35(66)19-42(65)49(71)60-29(3)31-9-11-32(12-10-31)45-30(4)59-26-73-45/h9-18,20-21,26-29,35,42,46,66H,19,22-25H2,1-8H3,(H,57,67)(H,58,69)(H,60,71)(H,61,70)(H,62,68)/t27-,28+,29-,35+,42-,46+/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: To be determined

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.