Phospho-Phospholamban (Ser16) Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB11410-50, MB11410-100

Product: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Swiss-Prot: P26678

Host: Rabbit

Reactivity: Human, Mouse

Applications: WB

All Applications: WB: 1/500-1/1000

Background: Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca2+. Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation.

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of Phospho-lamban in mouse heartLysates using Phospho-Phospho-lamban antibody.

Bioworld Molecular Weight: Calculated MW: 6 kDa; Observed MW: 12,24 kDa

Specificity: IgG

Alternative Name: PLN; PLB; Cardiac phospholamban; PLB

Immunogen: A synthetic phosphopeptide corresponding to residues surrounding Ser16 of human Phospholamban

Conjugate: Unconjugated

Modification: Phosphorylated