SOCS2 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS91266-50, BS91266-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: O14508(Human)

Host: Rabbit

Reactivity: Human

Applications: WB, ICC IF, IP,

All Applications: WB:1:500-1:2,000
ICC:1:50-1:200
IP:1:10-1:50

Background: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Purification and Purity: ProA affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Specificity: SOCS2 polyclonal antibody detects endogenous levels of SOCS2 protein.

Bioworld Molecular Weight: 22 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of SOCS2 on different lysates using anti-SOCS2 antibody at 1/1,000 dilution.
Positive control:
Lane 1: Human placenta
Lane 2: SH-SY-5Y, ICC staining SOCS2 in LOVO cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Alternative Name: SOCS-2, CIS-2, SSI-2, SOCS2, CIS2, SSI2, STATI2, CIS 2, CIS-2, CIS2, Cish 2, Cish2, Cytokine inducible SH2 protein 2, Cytokine-inducible SH2 protein 2, SOCS 2, SOCS-2, Socs2, SOCS2, SSI 2, SSI-2, SSI2, STAT induced STAT inhibitor 2, STAT-induced STAT inhibitor 2, STATI 2, STATI2, Suppressor of cytokine signaling 2,

Immunogen: Recombinant protein within human SOCS2 1-150aa.

Conjugate: Unconjugated

Modification: Unmodified