BMS961 is a potent and selective retinoic acid receptor gamma (RARγ) agonist with IC50 values of 30 nM. RARγ belongs to the family of nuclear receptors which regulates transcription. RARγ mediates the anti-proliferative and apoptotic effects of retinoids in cancer cells such as neuroblastoma cells. RARγ is the principal receptor that regulates RA mediated growth arrest in keratinocytes. In vitro, application of BMS961on mouse ear skin was found to cause a significant increase of thymic stromal lymphopoietin (TSLP) transcripts1. In addition, exposure of BMS861 on limbs at low concentration leads to retarded growth of the zeugopod (long bones) and intactness of autopod (paw). However, high concentration of BMS961treatment caused equal undifferentiation of both limb regions 2. In WT mice, RARγ agonists BMS961treatment resulted in an increase of the ear TSLP transcripts and serum TSLP, which indicates an involvement of RAR-mediated events in transcriptional activation of TSLP expression1.

Product information

CAS Number: 185629-22-5

Molecular Weight: 399.46

Formula: C23H26FNO4

Chemical Name: 3-fluoro-4-[(2S)-2-hydroxy-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)acetamido]benzoic acid

Smiles: CC1(C)CCC(C)(C)C2=CC(=CC=C12)[C@H](O)C(=O)NC1=CC=C(C=C1F)C(O)=O

InChiKey: AANFHDFOMFRLLR-IBGZPJMESA-N

InChi: InChI=1S/C23H26FNO4/c1-22(2)9-10-23(3,4)16-11-13(5-7-15(16)22)19(26)20(27)25-18-8-6-14(21(28)29)12-17(18)24/h5-8,11-12,19,26H,9-10H2,1-4H3,(H,25,27)(H,28,29)/t19-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.