Angiotensin I/II (2-7) is a peptide (ARG-VAL-TYR-ILE-HIS-PRO) that contains the amino acids 2-7 and is converted from Angiotensin I/II peptide. Angiotensin I is formed by the action of renin on angiotensinogen, an ǁ-2-globulin with 12 amino acids. Angiotensinogen is produced constitutively and released into the circulation mainly by the liver. Renin cleaves the peptide bond between the leucine (Leu) and valine (Val) residues on angiotensinogen, creating the ten-amino acid peptide angiotensin I. Angiotensin I is converted to angiotensin II (AII) through removal of two C-terminal residues by angiotensin-converting enzyme (ACE), primarily by ACE within the lung. Angiotensin is a peptide hormone that causes vasoconstriction and a subsequent increase in blood pressure. Angiotensin also stimulates the release of aldosterone, which promotes sodium retention in the distal nephron, thereby increasing blood pressure.

Product information

Molecular Weight: 783.92

Formula: C37H57N11O8

Chemical Name: (2R)-1-[(2S)-2-[(2S,3R)-2-[(2S)-2-[(2S)-2-[(2S)-2-amino-5-carbamimidamidopentanamido]-3-methylbutanamido]-3-(4-hydroxyphenyl)propanamido]-3-methylpentanamido]-3-(1H-imidazol-4-yl)propanoyl]pyrrolidine-2-carboxylic acid

Smiles: CC(C)[C@H](NC(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H]([C@H](C)CC)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N1CCC[C@@H]1C(O)=O

InChiKey: GIMXTZARSJSAAO-FPGPMUNZSA-N

InChi: InChI=1S/C37H57N11O8/c1-5-21(4)30(34(53)45-27(17-23-18-41-19-43-23)35(54)48-15-7-9-28(48)36(55)56)47-32(51)26(16-22-10-12-24(49)13-11-22)44-33(52)29(20(2)3)46-31(50)25(38)8-6-14-42-37(39)40/h10-13,18-21,25-30,49H,5-9,14-17,38H2,1-4H3,(H,41,43)(H,44,52)(H,45,53)(H,46,50)(H,47,51)(H,55,56)(H4,39,40,42)/t21-,25+,26+,27+,28-,29+,30+/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.