HMG4 Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB11040-50, MB11040-100

Product: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Swiss-Prot: O15347

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB

All Applications: WB: 1/500-1/1000

Background: Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters . Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor . Negatively regulates B-cell and myeloid cell differentiation. In hematopoietic stem cells may regulate the balance between self-renewal and differentiation. Involved in negative regulation of canonical Wnt signaling .

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of HMG4 in K562, C6, 3T3, HelaLysates using HMG4 antibody.

Bioworld Molecular Weight: Calculated MW: 23 kDa; Observed MW: 23 kDa

Specificity: IgG

Alternative Name: HMG4; HMG-4; HMG2A; HMG-2a

Immunogen: A synthetic peptide of human HMG4

Conjugate: Unconjugated

Modification: Unmodified