RON Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS91177-50, BS91177-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q04912(Human)

Host: Rabbit

Reactivity: Human

Applications: WB, ICC/IF, IHC, IP, , FC

All Applications: WB:1:1,000
ICC:1:50-1:200
IHC:1:50-1:200
FC:1:50-1:100

Background: Receptor protein tyrosine kinases (PTKs) have been classified into different subclasses on the basis of sequence similarity and distinct structural characteristics. The c-Met encoded receptor represents the initial member of one class of receptors characterized by a heterodimeric structure and a cysteine-rich extracellular domain. Ron, also designated macrophage-stimulating protein receptor (MSP receptor), p185-Ron, CD136 antigen or PTK8 represents a second member of this receptor class. The intracellular PTK domains of Ron and Met are highly similar (63% sequence identity) while the extracellular domains are less related (25% sequence identity) and both are rich in cysteine residues. Mature Ron receptor is comprised of a disulfide-linked heterodimer formed from an alpha chain (Ron α) and a beta chain (Ron β). Proteolytic processing results in the separation of the N-terminal Ron α and C-terminal Ron β subunits.

Purification and Purity: ProA affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: RON polyclonal antibody detects endogenous levels of RON protein.

Bioworld Molecular Weight: 185 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: ICC staining RON in A549 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS., ICC staining RON in AGS cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Alternative Name: MSP receptor, MST1R, c met related tyrosine kinase, CD136, CD136 antigen, CDw136, Macrophage stimulating 1 receptor (c met related tyrosine kinase), Macrophage stimulating 1 receptor, Macrophage stimulating protein receptor alpha chain, MACROPHAGE STIMULATING PROTEIN RECEPTOR, Macrophage stimulating protein receptor beta chain, Macrophage-Stimulating 1 Receptor (MST1R), Macrophage-stimulating protein receptor beta chain, MSP receptor, Mst1r, MST1R variant RON30, MST1R variant RON62, NPCA3, p185 RON, p185-Ron, Protein-tyrosine kinase 8, PTK 8, ptk8, PTK8 protein tyrosine kinase 8, Recepteur d’origine nantais (RON), RON, RON protein tyrosine kinase, RON variant E2E3, RON, Soluble RON variant 1, Soluble RON variant 2, Soluble RON variant 3, Soluble RON variant 4, Stem cell derived tyrosine kinase,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodified