GRK 5 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES2480-50, ES2480-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes (PMNs). [provided by RefSeq, Jul 2008],

Alternate Name: GRK5; GPRK5; G protein-coupled receptor kinase 5; G protein-coupled receptor kinase GRK5

Source: Rabbit

Applications: WB; IHC; IF; ELISA

Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.

Reactivity: Human; Mouse; Rat

Immunogen: The antiserum was produced against synthesized peptide derived from human GRK5. AA range:351-400

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 68kD

Human Gene ID: 2869

Human SWISS Prot NO: P34947

Subcellular Location: Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein. Predominantly localized at the plasma membrane; targeted to the cell surface through the interaction with phospholipids. Nucleus localization is regulated in a GPCR and Ca (2+)/calmodulin-dependent fashion.

Research Use Only