CD49f Monoclonal Antibody

Catalogue Numbers: MB65790-50, MB65790-100

Sizes: 50µl, 100µl

Product: Mouse IgG2a kappa. Liquid in PBS, pH 7.3, and 0.02% sodium azide.

Swiss-Prot: P23229

Host: Mouse

Reactivity: Human

Applications: IF, FC

All Applications: IF (1/50 - 1/200)

Background: Integrins are α/β heterodimeric cell surface receptors that play a pivotal role in cell adhesion and migration, as well as in growth and survival. The integrin family contains at least 18 α and 8 β subunits that form 24 known integrins with distinct tissue distribution and overlapping ligand specificities. Integrins not only transmit signals to cells in response to the extracellular environment (outside-in signaling), but also sense intracellular cues to alter their interaction with the extracellular environment (inside-out signaling).
Integrin α6 is a 120 kDa protein with two splice variants, integrin α6, 6A and 6B, which function as receptors for laminins on the basal membrane to mediate cellular adhesion events. α6 integrins have been shown to play an important role in hematopoietic stem and progenitor cell homing to the bone marrow.

Purification and Purity: The monoclonal antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Recognizes human CD49f

Extra Notes: Flow cytometric analysis of human peripheral blood lymphocytes using Anti-CD49f Antibody, followed by anti-mouse IgG PE.

Bioworld Molecular Weight: ~ 126 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: Integrin alpha-6; CD49 antigen-like family member F; VLA-6; CD antigen CD49f)

Immunogen: Native purified human CD49f.

Conjugate: Unconjugated

Modification: Unmodified