FA12(heavy Chain,Cleaved-Ile20)Polyclonal Antibody

Product: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Catalogue Numbers: BS65134-50, BS65134-100

Sizes: 50µl, 100µl

Swiss-Prot: P00748

Host: Rabbit

Reactivity: Human

Applications: WB,IHC-p,If (paraffin section),ELISA

Background: coagulation factor XIi (F12) Homo sapiens This gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activat

Product: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity: Cleaved-Factor XII HC (I20) Polyclonal Antibody detects endogenous levels of fragment of activated Factor XII HC protein resulting from cleavage adjacent to I20.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of FA12 (heavy chain, Cleaved-Ile20) Antibody. The lane on the right is blocked with the FA12 (heavy chain, Cleaved-Ile20) peptide., Immunohistochemistryt analysis of paraffin-embedded human lung carcinoma, using FA12 (heavy chain, Cleaved-Ile20) Antibody. The lane on the right is blocked with the FA12 (heavy chain, Cleaved-Ile20) peptide.

Bioworld Molecular Weight: ~ 41 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Alternative Name: F12; Coagulation factor XII; Hageman factor; HAF

Immunogen: The antiserum was produced against synthesized peptide derived from human FA12. AA range:1-50

Conjugate: Unconjugated

Modification: Cleaved