ML604440 is a potent, specific and cell permeable proteasome β1i (LMP2) subunit inhibitor.ML604440 impairs MHC class I cell surface expression, IL-6 secretion and differentiation of naïve T helper cells to T helper 17 cells. ML604440 strongly ameliorates disease in experimental colitis and EAE.

Product information

CAS Number: 1140517-08-3

Molecular Weight: 388.19

Formula: C17H24BF3N2O4

Chemical Name: [(1R)-3-methyl-1-(2-methyl-2-{[2-(trifluoromethyl)phenyl]formamido}propanamido)butyl]boronic acid

Smiles: CC(C)(NC(=O)C1=CC=CC=C1C(F)(F)F)C(=O)N[C@@H](CC(C)C)B(O)O

InChiKey: IRZZVDHGNHGNAI-ZDUSSCGKSA-N

InChi: InChI=1S/C17H24BF3N2O4/c1-10(2)9-13(18(26)27)22-15(25)16(3,4)23-14(24)11-7-5-6-8-12(11)17(19,20)21/h5-8,10,13,26-27H,9H2,1-4H3,(H,22,25)(H,23,24)/t13-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 100 mg/mL (257.61 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.