NFPS is a selective, non-competitive glycine transporter-1 (GlyT1) inhibitor with IC50s of 2.8 nM and 9.8 nM for hGlyT1 and rGlyT1, respectively. NFPS exerts neuroprotection via glyR alpha1 subunit in the rat model of transient focal cerebral ischaemia and reperfusion.

Product information

CAS Number: 405225-21-0

Molecular Weight: 393.45

Formula: C24H24FNO3

Chemical Name: 2-{[(3S)-3-{[1,1'-biphenyl]-4-yloxy}-3-(4-fluorophenyl)propyl](methyl)amino}acetic acid

Smiles: CN(CC(O)=O)CC[C@H](OC1C=CC(=CC=1)C1C=CC=CC=1)C1C=CC(F)=CC=1

InChiKey: FDORQEIHOKEJNX-QHCPKHFHSA-N

InChi: InChI=1S/C24H24FNO3/c1-26(17-24(27)28)16-15-23(20-7-11-21(25)12-8-20)29-22-13-9-19(10-14-22)18-5-3-2-4-6-18/h2-14,23H,15-17H2,1H3,(H,27,28)/t23-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.