GABA A Receptor α4 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES20748-50, ES20748-100

Citations, Manuals and MSDS Available upon request.

Background: Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. This gene encodes subunit alpha-4, which is involved in the etiology of autism and eventually increases autism risk through interaction with another subunit, gamma-aminobutyric acid receptor beta-1 (GABRB1). Alternatively spliced transcript variants encoding different isoforms have been found in this gene.[provided by RefSeq, Feb 2011],

Alternate Name: GABRA4; Gamma-aminobutyric acid receptor subunit alpha-4; GABA (A) receptor subunit alpha-4

Source: Rabbit

Applications: WB; IHC; IF

Dilution: WB 1:1000-2000, IHC 1:100-200

Reactivity: Human; Rat; Mouse

Immunogen: Synthetic Peptide of GABA A Receptor α4 AA range: 149-199

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 62kD

Human Gene ID: 2557

Human SWISS Prot NO: P48169

Subcellular Location: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Research Use Only