Hexim2 Polyclonal Antibody

Catalogue Numbers: BS60281-50, BS60281-100

Sizes: 50µl, 100µl

Alternative Name: Protein HEXIM2; Hexamethylene bis-acetamide-inducible protein 2; ORF Names: L3

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q96MH2

Host: Rabbit

Reactivity: Human

Applications: WB

All Applications: WB: 1:500~1:1000

Background: Hexamethylene bis-acetamide inducible 1 (HEXIM1) and Hexamethylene bisacetamide inducible 2 (HEXIM2) comprise a family of proteins, which inhibit positive transcription elongation factor b (P-TEFb) through association with 7SK. P-TEFb is composed of a catalytic subunit Cdk9 and either Cyclin T1 or T2 as a regulatory subunit. This complex regulates eukaryotic gene expression at the level of elongation. The C-terminal domains of HEXIM proteins interact directly with each other. Via these domains, HEXIM1 and HEXIM2 form stable homo- and hetero-oligomers, which may aid in the formation of the 7SK small nuclear ribonucleic acid particle. Despite their similar functions, HEXIM1 and HEXIM2 exhibit distinct expression patterns in various established cell lines and human tissues.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Hexim2 polyclonal antibody detects endogenous levels of Hexim2 protein.

Bioworld Molecular Weight: ~ 32,43 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of Hexim2 polyclonal antibody at 1:500 dilution
Lane 1: HEK293T cell lysate
Lane 2: A549 cell lysate

Immunogen: A synthetic peptide corresponding to residues in Human Hexim2.

Conjugate: Unconjugated

Modification: Unmodified