PF-622 is a potent, time-dependent, irreversible FAAH inhibitor . Fatty acid amide hydrolase (FAAH), belongs to a member of an unusual class of serine hydrolases, is an integral membrane enzyme involved in regulating the fatty acid amide family of lipid transmitters. Genetic or pharmacological inactivation of FAAH leads to elevated endogenous levels of fatty acid amides with analgesic, anti-inflammatory, anxiolytic, and antidepressant phenotypes. The FAAH is an attractive drug target for the treatment of pain . In vitro: PF-622 inhibited the activity of FAAH in a time-dependent manner with the IC50 values of 0.99 and 0.033 μM in human recombinant FAAH for 5 and 60 minutes, respectively . In various human and murine tissue proteome samples, PF-622 showed highly selectivity for FAAH in relative to other serine hydrolases, showing no discernable off-site activity up to 500 μM . PF-622 at 1 μM decreased IL-2 production in both healthy subjects and in HCV patients .

Product information

CAS Number: 898235-65-9

Molecular Weight: 346.43

Formula: C21H22N4O

Chemical Name: N-phenyl-4-[(quinolin-2-yl)methyl]piperazine-1-carboxamide

Smiles: O=C(NC1C=CC=CC=1)N1CCN(CC2=CC=C3C=CC=CC3=N2)CC1

InChiKey: SNTCRRMCALVGNL-UHFFFAOYSA-N

InChi: InChI=1S/C21H22N4O/c26-21(23-18-7-2-1-3-8-18)25-14-12-24(13-15-25)16-19-11-10-17-6-4-5-9-20(17)22-19/h1-11H,12-16H2,(H,23,26)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.