HBG1/HBG2 Polyclonal Antibody

Sizes: 60μL, 120μL, 200μL

Catalogue Numbers: E-AB-18774-60, E-AB-18774-120, E-AB-18774-200

Citations, Manuals and MSDS Available upon request.

Abbreviation: HBG1/HBG2

Target Synonym: A gamma globin; G gamma globin; Gamma 1 globin; Gamma 2 globin; Gamma A hemoglobin; Gamma globin; Hb F Agamma; Hb F Ggamma; hbfagamma; hbfggamma; HBG 1; HBG 2; HBG1; HBG2; HBGA; HBGR; Hemoglobin gamma 1 chain ; Hemoglobin gamma 2 chain ; Hemoglobin gamma A; Hemoglobin gamma A chain ; Hemoglobin gamma G; Hemoglobin gamma G chain ; Hemoglobin gamma regulator of; Hemoglobin subunit gamma 1; Hemoglobin subunit gamma 2; HSGGL 1; HSGGL1; Methemoglobin; PRO 2979; PRO2979

Research Areas: Cardiovascular

Conjugation: Unconjugated

Host: Rabbit

Species Reactivity: Human

Application: WB, IHC, ELISA

Isotype: IgG

Clonality: Polyclonal

UNIProt ID: P69891,P69892

Background: The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'.

Concentration: 0.6 mg/mL

Immunogen: Fusion protein of human HBG1/HBG2

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Purification Method: Antigen affinity purification

Dilution: WB 1:500-1:2000, IHC 1:40-1:200, ELISA 1:5000-1:10000

Calculated MW: 16 kDa

Storage: -20°C/One year. Avoid freeze / thaw cycles.

Shipping: Ice bag

Research Use Only