Dyrk1B (T356) Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS2677-50, BS2677-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q9Y463

Host: Rabbit

Reactivity: Human, Mouse

Applications: IHC

All Applications: IHC: 1:50~1:200

Background: Dyrk (for dual specificity tyrosine phosphorylation regulated kinase) is the homolog of the Drosophila mnb (minibrain) gene which is required for neurogenesis. Dyrk is a dual-specificity tyrosine kinase and serine/threonine kinase, which is self regulated by tyrosine phosphorylation. Several related mammalian proteins compose the Dyrk family of dual specificity protein kinases, including Dyrk1A, Dyrk1B, Dyrk1C, Dyrk2, Dyrk3, Dyrk4A and Dyrk4B. The Dyrk family members are thought to be involved in the regulation of cellular growth and/or development. Dyrk1B localizes to the nucleus in muscle and testis. Specifically, Dyrk1B plays a critical role in muscle differentiation by regulating motility, transcription, cell cycle progression and cell survival. Dyrk1B is also found is several solid tumors, where it acts as a downstream effector of Rac1 or K-ras to mediate cell survival.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Immunohistochemistry (IHC) analyzes of Dyrk1B (T356) pAb in paraffin-embedded human tonsil carcinoma tissue at 1:50.

Bioworld Molecular Weight: ~ 69,66 kDa

Specificity: Dyrk1B (T356) polyclonal antibody detects endogenous levels of Dyrk1B protein.

Alternative Name: Dual specificity tyrosine-phosphorylation-regulated kinase 1B; Minibrain-related kinase; Mirk protein kinase; DYRK1B; MIRK

Immunogen: Synthetic peptide, corresponding to amino acids 325-372 of Human Dyrk1B.

Conjugate: Unconjugated

Modification: Unmodified